On Thursday, 02/02/2023, Professor Shigeo Ohta PhD, as part of his day-long visit on the invitation of the European Academy for Molecular Hydrogen Research in Biomedicine and the Center for Experimental Medicine, of Slovak Academy of Sciences, gave an excellent 60-minute lecture on the topic: Why is molecular hydrogen „too“ good for our health? From the initiation of hydrogen medicine to the resolution of elusive questions.
The seminar was attended by more than 50 scientists. In the presentation and rich discussion lasting more than 40 mins, Prof. Ohta also presented his hypothesis, which explains the so far missing answer to the pluripotent effect of molecular hydrogen in medicine. The hypothesis can be found bellow.
Prof. Ohta’s visit was supported by H2World
A summary of the main working hypotheses based on recent findings
1. Q: H2 was considered an inert and unreactive gas in the absence of a catalyst. There was a large difference in the kinetics of the H2 – ·OH reaction between living cells and aqueous solutions.
Answer: The hydride form of the porphyrin (PrPFe(III)-H) was found to catalyze the reaction between H2 and ·OH, which resolved the contradiction.
2. Question: H2 has different functions in the living body.
Answer: Different porphyrins are distributed in the body with different functions in oxidative stress: in hemoglobin, myoglobin, mitochondrial electron transport chain, P450 for detoxification, NO synthase, catalase, peroxidase and mitochondrial K+-channel. If H2 could restore the damaged (oxidized) form (Fe(III)-OH porphyrin), the obtained porphyrins should be activated to show different functions in the body.
3. Question: When you drink H2-rich water, the H2 is exhaled from the lungs, so H2 does not reach the arterial blood, brain, skeletal muscle and kidneys due to the exhalation of H2 through the lungs, but no doubt the beneficial effects on the brain have been repeatedly observed in animal experiments , skeletal muscle, kidney and arterial blood vessel.
Answer: Although the H2 molecule itself has expired, the hybrid form of porphyrin Fe(III) can circulate in the body as a carrier of H.
The working hypothesis is still speculative.